Future Science: RNA Sequencing (Transcriptomics) Predicts Embryo Viability Better than PGT-A

Written By camellia chen

【Abstract】: (R&D Update) A groundbreaking paper published in Nature Medicine suggests that analyzing the RNA profile (transcriptome) of the spent culture media is 15% more accurate in predicting live birth potential than traditional DNA-based PGT-A. This "functional" testing looks at what the embryo is doing, not just what it is.

Business Insight: If validated, we are looking at the next generation of genetic testing products: "PGT 4.0". This moves the industry from detecting aneuploidy (chromosomes) to detecting metabolic viability. Genetic testing companies need to pivot their R&D pipelines toward transcriptomics immediately to avoid obsolescence in the 2027-2028 market cycle.

  1. 【Keywords】: #Transcriptomics #RNASeq #FutureOfPGT

  2. 【Source】: Nature Medicine (Feb 10, 2026)

camellia chen
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